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There are three helpings of NFL football on the menu for Thanksgiving Day again this season, while the marquee Sunday night betting matchup offers up a battle between the Green Bay Packers and the New York Giants at MetLife Stadium. Here's a look at the matchups and NFL betting odds for this week's schedule of pro pigskin action.

Week 11 went slightly to the favorites in NFL betting circles, fuelled by the surprise Monday Night rout by the 49ers over the Bears.

And Week 12 opening lines shape up with a full slate of games (bye weeks are over), many of which showcase very tight odds.

Four games did not get an opening line Tuesday as injury situations in Chicago, San Francisco, Philadelphia and Baltimore kept those games off the board at online sportsbooks and in Vegas.

Favorites were 7-6-1 ATS in Week 11, with home teams holding an 8-6 SU edge. Totals betting trended slightly UNDER the number at 8-6.

Two teams dealing with playoff races and injured starting quarterbacks square-off when the 6-2-1 San Francisco 49ers host the 7-2 Chicago Bears for this week's edition of Monday Night Football (8:30 pm ET, ESPN).

On one side of this matchup Chicago started 1-1 this season, then won six games in a row, thanks in large part to a defense that's scored seven touchdowns on the year. Last week, though, the Bears fell at home to Houston 13-6.

Chicago lost more than a game last Sunday night, as QB Jay Cutler got knocked out of action with a head injury.

Andrew Luck and the Indianapolis Colts have been a solid wager against the NFL betting odds so far this season, but they'll run into a tough road matchup on Sunday afternoon this week as they take on Tom Brady and the New England Patriots in one of the marquee contests on the Week 11 slate.

After a slow start to this season the Pittsburgh Steelers look like they're kicking their game into gear.

The Kansas City Chiefs, meanwhile, look like contenders for the title of “worst team in the league.”

So it's an apparent mis-match as the Steelers and Chiefs get ready to do battle on this week's edition of Monday Night Football (8:30 pm ET, ESPN).