Clemson Tigers Game Logs
| event date | Opponent | Type | Result | score | ATS | Line | OU | Total | preview available | recap available |
|---|---|---|---|---|---|---|---|---|---|---|
| Sep 4, 2021 | vs Georgia | REG | L | 10-3 | L | -3 | U | 51.5 | Preview | Recap |
| Sep 11, 2021 | vs South Carolina State | REG | W | 49-3 | L | -50.5 | U | 56 | Preview | No |
| Sep 18, 2021 | vs Georgia Tech | REG | W | 14-8 | L | -27.5 | U | 52.5 | Preview | Recap |
| Sep 25, 2021 | @ North Carolina State | REG | L | 27-21 | L | -10.5 | O | 47.5 | Preview | Recap |
| Oct 2, 2021 | vs Boston College | REG | W | 19-13 | L | -14.5 | U | 46.5 | Preview | Recap |
| Oct 15, 2021 | @ Syracuse | REG | W | 17-14 | L | -13.5 | U | 44 | Preview | Recap |
| Oct 23, 2021 | @ Pittsburgh | REG | L | 27-17 | L | 3.5 | U | 47 | Preview | Recap |
| Oct 30, 2021 | vs Florida State | REG | W | 30-20 | W | -9.5 | O | 47.5 | Preview | Recap |
| Nov 6, 2021 | @ Louisville | REG | W | 30-24 | W | -3.5 | O | 46.5 | Preview | Recap |
| Nov 13, 2021 | vs Connecticut | REG | W | 44-7 | L | -40.5 | O | 50.5 | Preview | Recap |
| Nov 20, 2021 | vs Wake Forest | REG | W | 48-27 | W | -3.5 | O | 57 | Preview | Recap |
| Nov 27, 2021 | @ South Carolina | REG | W | 30-0 | W | -11.5 | U | 42.5 | No | Recap |
| Dec 29, 2021 | @ Iowa State | PST | W | 20-13 | W | -2 | U | 45 | Preview | Recap |