Purdue Boilermakers Game Logs
| event date | Opponent | Type | Result | score | ATS | Line | OU | Total | preview available | recap available |
|---|---|---|---|---|---|---|---|---|---|---|
| Sep 4, 2021 | vs Oregon State | REG | W | 30-21 | W | -7 | U | 68 | Preview | Recap |
| Sep 11, 2021 | @ Connecticut | REG | W | 49-0 | W | -35 | U | 57 | Preview | Recap |
| Sep 18, 2021 | @ Notre Dame | REG | L | 27-13 | L | 7.5 | U | 58.5 | Preview | Recap |
| Sep 25, 2021 | vs Illinois | REG | W | 13-9 | L | -10.5 | U | 53 | Preview | Recap |
| Oct 2, 2021 | vs Minnesota | REG | L | 20-13 | L | -2.5 | U | 46.5 | Preview | Recap |
| Oct 16, 2021 | @ Iowa | REG | W | 24-7 | W | 11.5 | U | 42.5 | Preview | Recap |
| Oct 23, 2021 | vs Wisconsin | REG | L | 30-13 | L | 3.5 | O | 41 | Preview | Recap |
| Oct 30, 2021 | @ Nebraska | REG | W | 28-23 | W | 7.5 | U | 54 | Preview | Recap |
| Nov 6, 2021 | vs Michigan State | REG | W | 40-29 | W | 2.5 | O | 53.5 | Preview | Recap |
| Nov 13, 2021 | @ Ohio State | REG | L | 59-31 | L | 19 | O | 65.5 | Preview | Recap |
| Nov 20, 2021 | @ Northwestern | REG | W | 32-14 | W | -11 | U | 47.5 | Preview | Recap |
| Nov 27, 2021 | vs Indiana | REG | W | 44-7 | W | -17.5 | O | 50.5 | No | Recap |
| Dec 30, 2021 | vs Tennessee | PST | W | 48-45 | W | 7.5 | O | 67 | Preview | Recap |