East Carolina Pirates Game Logs
| event date | Opponent | Type | Result | score | ATS | Line | OU | Total | preview available | recap available |
|---|---|---|---|---|---|---|---|---|---|---|
| Sep 2, 2021 | @ Appalachian State | REG | L | 33-19 | L | 9 | U | 56 | Preview | Recap |
| Sep 11, 2021 | vs South Carolina | REG | L | 20-17 | L | 2.5 | U | 56.5 | Preview | Recap |
| Sep 18, 2021 | @ Marshall | REG | W | 42-38 | W | 10.5 | O | 58.5 | Preview | Recap |
| Sep 25, 2021 | vs Charleston Southern | REG | W | 31-28 | L | -24.5 | P | 59 | Preview | No |
| Oct 2, 2021 | vs Tulane | REG | W | 52-29 | W | 3 | O | 64.5 | Preview | Recap |
| Oct 9, 2021 | @ Central Florida | REG | L | 20-16 | W | 10 | U | 64.5 | Preview | Recap |
| Oct 23, 2021 | @ Houston | REG | L | 31-24 | W | 13.5 | U | 56.5 | Preview | Recap |
| Oct 28, 2021 | vs South Florida | REG | W | 29-14 | W | -9.5 | U | 55.5 | Preview | Recap |
| Nov 6, 2021 | vs Temple | REG | W | 45-3 | W | -15.5 | U | 52 | Preview | Recap |
| Nov 13, 2021 | @ Memphis | REG | W | 30-29 | W | 4 | P | 59 | Preview | Recap |
| Nov 20, 2021 | @ Navy | REG | W | 38-35 | L | -3.5 | O | 46.5 | Preview | Recap |
| Nov 26, 2021 | vs Cincinnati | REG | L | 35-13 | L | 14.5 | U | 56.5 | No | Recap |