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San Francisco 49ers vs Buffalo Bills Recap - Bills Win 35-10

The 49ers had no answer for James Cook on Sunday as the Bills rolled to a 35-10 win at Highmark Stadium.

Buffalo was the ATS victor, as they covered the -6.5-point spread as a favorite. Over-Under bettors who played UNDER the total of 45.5 were rewarded at the payout window.

James Cook rushed for 107 yards, while Ray Davis added 63 yards in the win. Dawson Knox and Khalil Shakir added 56 and 30 receiving yards respectively.

Jordan Mason rushed for 78 yards for San Francisco, while Christian McCaffrey added 53 yards. Brock Purdy threw for 94 yards for the 49ers, while receivers Jauan Jennings and Deebo Samuel Sr. had 56 and 20 yards respectively.

San Francisco was outgained by Buffalo 372-239 yards in Sunday's match, while the important battle of first downs was won 20-15 by the Bills.

San Francisco lost the time of possession battle 33:27-26:33, leaving their defense on the field more than they wanted.

Buffalo looks to continue their winning ways next game with a battle against the Rams. The 49ers will aim to get back on the winning track vs. Chicago.