Iowa State Cyclones Game Logs
| event date | Opponent | Type | Result | score | ATS | Line | OU | Total | preview available | recap available |
|---|---|---|---|---|---|---|---|---|---|---|
| Sep 4, 2021 | vs Northern Iowa | REG | W | 16-10 | L | -28.5 | U | 50 | Preview | No |
| Sep 11, 2021 | vs Iowa | REG | L | 27-17 | L | -4 | U | 45 | Preview | Recap |
| Sep 18, 2021 | @ Nevada-Las Vegas | REG | W | 48-3 | W | -32 | U | 53 | Preview | Recap |
| Sep 25, 2021 | @ Baylor | REG | L | 31-29 | L | -7 | O | 46 | Preview | Recap |
| Oct 2, 2021 | vs Kansas | REG | W | 59-7 | W | -34.5 | O | 57 | Preview | Recap |
| Oct 16, 2021 | @ Kansas State | REG | W | 33-20 | W | -6.5 | O | 51 | Preview | Recap |
| Oct 23, 2021 | vs Oklahoma State | REG | W | 24-21 | L | -7 | U | 47 | Preview | Recap |
| Oct 30, 2021 | @ West Virginia | REG | L | 38-31 | L | -7.5 | O | 49 | Preview | Recap |
| Nov 6, 2021 | vs Texas | REG | W | 30-7 | W | -6 | U | 59.5 | Preview | Recap |
| Nov 13, 2021 | @ Texas Tech | REG | L | 41-38 | L | -13 | O | 55.5 | Preview | Recap |
| Nov 20, 2021 | @ Oklahoma | REG | L | 28-21 | L | 3 | U | 59 | Preview | Recap |
| Nov 26, 2021 | vs Texas Christian | REG | W | 48-14 | W | -15.5 | O | 61 | No | Recap |
| Dec 29, 2021 | vs Clemson | PST | L | 20-13 | L | 2 | U | 45 | Preview | Recap |