San Francisco 49ers Game Logs
| event date | Opponent | Type | Result | score | ATS | Line | OU | Total | preview available | recap available |
|---|---|---|---|---|---|---|---|---|---|---|
| Sep 13, 2020 | vs Arizona | REG | L | 24-20 | L | -7 | U | 48.5 | Preview | Recap |
| Sep 20, 2020 | @ NY Jets | REG | W | 31-13 | W | -7 | O | 41.5 | Preview | Recap |
| Sep 27, 2020 | @ NY Giants | REG | W | 36-9 | W | -3 | O | 43.5 | Preview | Recap |
| Oct 4, 2020 | vs Philadelphia | REG | L | 25-20 | L | -8.5 | U | 46 | Preview | Recap |
| Oct 11, 2020 | vs Miami | REG | L | 43-17 | L | -8 | O | 50.5 | Preview | No |
| Oct 18, 2020 | vs LA Rams | REG | W | 24-16 | W | 2.5 | U | 51.5 | Preview | No |
| Oct 25, 2020 | @ New England | REG | W | 33-6 | W | 3 | U | 44.5 | Preview | No |
| Nov 1, 2020 | @ Seattle | REG | L | 37-27 | L | 1 | O | 54.5 | Preview | Recap |
| Nov 5, 2020 | vs Green Bay | REG | L | 34-17 | L | 6 | O | 48.5 | Preview | Recap |
| Nov 15, 2020 | @ New Orleans | REG | L | 27-13 | L | 9.5 | U | 49.5 | Preview | Recap |
| Nov 29, 2020 | @ LA Rams | REG | W | 23-20 | W | 5 | U | 44.5 | Preview | Recap |
| Dec 7, 2020 | vs Buffalo | REG | L | 34-24 | L | -1.5 | O | 48 | Preview | Recap |
| Dec 13, 2020 | vs Washington | REG | L | 23-15 | L | -3 | U | 43.5 | Preview | Recap |
| Dec 20, 2020 | @ Dallas | REG | L | 41-33 | L | -3.5 | O | 45.5 | Preview | Recap |
| Dec 26, 2020 | @ Arizona | REG | W | 20-12 | W | 6 | U | 49 | Preview | Recap |
| Jan 3, 2021 | vs Seattle | REG | L | 26-23 | W | 7 | O | 45 | Preview | Recap |